Natural Product Chemistry Lab @ Sookmyung Women's University

Latest News

July 23 - 28, 2022

Houng and Eunah represent our lab in 2022 ASP (American Society of Pharmacognosy) annual meeting in Charleston, South Carolina!

May 25, 2020

Today was Kyo Bin's birthday; and we were informed that now we are a part of the Muscle Physiome Research Center (MPRC), funded by the National Research Foundation of Korea (NRF)'s medical research center (MRC) team grant for 7 years!

March 30 - April 1, 2022

Our lab participated in 2022 Annual Symposium of the Korea Metabolomics Society, which was held in Busan, Korea.


+ Conference = new lab photos!

February 25, 2022

Congratulations Eunjin and Eunah for M.Sc. graduation!

Eunah won this semester's outstanding thesis award.

January 25, 2022

Huong published her work on specialized metabolites induced by a non-antagonistic co-culture between mushroom-forming fungi in Journal of Natural Products! This work was the major theme of her master thesis.

https://pubs.acs.org/doi/10.1021/acs.jnatprod.1c01022

January 6, 2022

Our first publication in this year came out in Analytical Chemistry! In this study, we demonstrated that MS/MS molecular networking is a powerful and efficient tool for detecting drug metabolites from LC-MS datasets, by comparing molecular networking with other commercial software.

Special thanks to Mr. Jun Sang Yu and Prof. Hye Hyun Yoo (Hanyang University) for the collaborative efforts on this work.

https://doi.org/10.1021/acs.analchem.1c04925

December 20-22, 2021

Our lab participated in 2021 Fall International Convention of the Pharmaceutical Society of Korea.

Huong's abstract was selected for a 5-min talk in the young scientist's session, so she gave her first time conference talk. Congratulations!


+ Conference = new lab photos!

November 8, 2021

Finally we could take graduation pictures with Huong. Congratulations again!


September 29, 2021

Our lab is awarded an international cooperative grant named <Science and Technology Amicable Relationships (South Korea-France)>! We will collaborate with Prof. Mehdi Beniddir's group at Université Paris-Saclay to discover bioactive monoterpene indole alkaloids from plants, applying untargeted MS/MS-based metabolomics approaches.

August 25, 2021

Huong finished her Msc, winning the University outstanding thesis award. The current COVID-19 situation did not allow us to take any graduation cap and gown pictures... but congratulations Huong!!

She will continue following her scientific endeavor on natural product chemistry in our lab as a PhD student.


Thesis title: Sesquiterpenes induced by the co-cultivation of Phellinus orientoasiaticus and Schizopora flavipora

June 18, 2021

Our latest review paper is published in Natural Product Reports! Here we described our vision on the future of MS- and NMR-based computational metabolomics approaches for metabolite annotation.

This review was written as an international collaboration with colleagues from all around the world: Mehdi Beniddir (Paris-Saclay University, France),Grégory Genta-Jouve (Université De Guyane, French Guiana), Florian Huber (Netherlands eScience Center, The Netherlands), Simon Rogers (University of Glasgow, UK), and Justin J. J. van der Hooft (Wageningen University, The Netherlands).

https://doi.org/10.1039/D1NP00023C

March 31 - April 2, 2021

Our lab participated in 2021 Annual Symposium of the Korea Metabolomics Society, which was held in Jeju, Korea.

March 1, 2021

Yesterday was Sunmin's last day in our lab. She will move to the Quave lab at Emory University as a postdoc and keep pursuing her enthusiasm in natural product chemistry. Thanks for a lot of works and helps Sunmin provided for the last 6 months!

Today, three new Master course students, Kyungha, Seunghyun, and Dayoung joined our lab. Welcome aboard!

February 3, 2021

Our paper on the sample prioritization strategy based on estimation of scaffold uniqueness applying a LC-MS/MS-based metabolomics pipeline is published in Journal of Natural Products!

Special thanks to Prof. Woo Young Kim (Sookmyung Women's University), Prof. Young Woon Lim (Seoul National University), and Prof. Ki Hyun Kim (Sungkyunkwan University) for the collaborative efforts.

And a huge congratulations Huong for her first first-authored paper!

https://pubs.acs.org/doi/10.1021/acs.jnatprod.0c00977

December 12, 2020

Sunmin gave a great talk in young scientist session of the e-conference of Korean Society of Pharmacognosy! She presented the results from her PhD works on selaginellin derivatives from Selaginella tamariscina.

November 6, 2020

Our paper on the genetic and chemical diversity of Taraxacum plants occurring in the Korean Peninsula is now published in Phytochemitry!

This study started as a collaborative study between the late Prof. Sang Hyun Sung's lab and Prof. Tae-Jin Yang's lab in Seoul National University 5 years ago. Thanks and congratulations to everyone who contributed to this work, especially Dr. Yun Sun Lee, MS. Jinkyung Kim, and Dr. Sunmin Woo.


https://doi.org/10.1016/j.phytochem.2020.112576

September 1, 2020

Dr. Sunmin Woo joined our lab as a new postdoctoral researcher. Welcome!

July 31, 2020

A new LC-MS system (Waters Vion IMS QToF) is starting to be installed in our lab!!

July 10, 2020

Kyo Bin gave the first Korean GNPS workshop as a part of 2020 Summer Symposium of the Korean Society of Pharmacognosy, which was held as an online symposium. More than 100 researchers participated in the workshop. We expect this workshop will expand the GNPS community and spread the concept of open data science in Korea!

May 13, 2020

The step-by-step protocol paper for building MS/MS molecular networking in the GNPS platform is now available in Nature Protocols! We are so proud to participate in this international community-driven project!


https://doi.org/10.1038/s41596-020-0317-5

March 2, 2020

Two new master course students, Eun Jin and Eun Ah, joined our lab. Welcome!

February 26, 2020

Now it is official! Our lab will be supported by the National Research Foundation of Korea (NRF) grant for applying an integrated genome-mining and metabolomics workflow for drug discovery from massive fungal strain collections for 5 years! Stay tunes for how awesome sciences will come from our lab!

February 13, 2020

First publication alert in 2020! Our group's is now available in Phytochemistry! It describes a showcase on how we can use LC-MS/MS data analysis workflows recently developed in GNPS, such as MolNetEnhancer, Chemical Structural and Compositional Similarity, and Bioactivity networking to reveal chemical diversity and predict bioactive components from multiple number of plant extracts.


https://doi.org/10.1016/j.phytochem.2020.112292

January 10, 2020

Kyo Bin participated this winter's Tiny Earth Partner Instructor training which was held in Madison, Wisconsin, USA. Tiny Earth is a network of instructors and students focused on student-sourcing antibiotic discovery from soil. As a partner lab of Tiny Earth, we will open a discovery-oriented lab class for undergraduate students in the next fall semester, and will apply microbiological diversity found in the class into the antibiotics discovery in our lab.


More information about Tiny Earth can found in:

https://tinyearth.wisc.edu/

December 30, 2019

Our lab's first dinner event for saying goodbye to 2019, and saying goodbye to Dr. Seung -Yun Oh who will be back to Suncheon National University.

His visiting in our lab was full of fun and awesome science; very interesting findings from our collaborative works on lichen collections will be out soon!

August 30, 2019

Today was the last day of our 5 undergraduate students' summer internship. As first members of our lab, they helped a lot of works for several projects. Thanks everyone!

Although they leave, the lab will not be empty; from the next month, two new members will join the lab!

A Vietnamese student Thi Huong Pham flied to Seoul and started her Master course from this month, and Seung-Yoon Oh, who is a mycologist and is working as a postdoc in Korean Lichen Research Institute, will stay in our lab as a visiting researcher for three months.

Welcome newcomers!

June 22, 2019

Our latest paper is available at Journal of Natural Products! It describes the prioritization and targeted isolation of selaginellin derivatives from Selaginella tamariscina, and their biological evaluation against PDE-4 activity. It's a showcase of how you can use MS/MS molecular networking for targeting a specific molecular scaffold of interest even when you don't have any related compound or reference spectrum. Especially thanks to Ms. Sunmin Woo (Seoul National University) for her contribution to this study!


https://pubs.acs.org/doi/10.1021/acs.jnatprod.9b00049

June 1, 2019

Please to announce that our group won the research grant project titled "Bioactive natural product discovery from Polyporaceae mushrooms based on metabolites profiling", which is supported by National Research Foundation of Korea. We will investigate on the chemical diversity of Polyporaceae mushrooms, many species of which have been used in East Asian traditional medicines, using mass spectrometry-based metabolomics techniques!

May 31, 2019

Proud to be a part of this international and collaborative work resulting MolNetEnhancer, which is an integrative metabolomic information mining and annotation tool! Our previous work on Rhamnaceae plant metabolites is also shown as a showcase. Special thanks to Dr. Justin J. J. van der Hooft and Dr. Madeleine Ernst for making this available!


Preprint available at Biorxiv: https://www.biorxiv.org/content/10.1101/654459v1


*update on July 16

Now the article is published in Metabolites!

https://www.mdpi.com/2218-1989/9/7/144

Mar 1, 2019

Our new paper is now out in Molecules! It describes the protective effect of 3-dehydroxyceanothetric acid 2-methyl ester, which were isolated from the roots of Ziziphus jujuba in our previous study, against cisplatin-induced cytotoxicity in kidney epithelial cells.


https://www.mdpi.com/1420-3049/24/5/878

Feb 20, 2019

Our new paper is now out in the Plant Journal! It describes an integrated data analysis workflow for comprehensive and automated metabolite annotation in untargeted metabolomics studies dealing with massive MS/MS dataset.


https://doi.org/10.1111/tpj.14292

Sep 1, 2018

Hello, world!

Our lab launched at College of Pharmacy, Sookmyung Women's University, Seoul, Korea.