Natural Products Metabolomics Lab @ Sookmyung Women's University
(# denotes shared first-authorship while * denotes co-correspondence.)
Representative papers
Qualitative metabolomics-based characterization of a phenolic UDP-xylosyltransferase with a broad substrate spectrum from Lentinus brumalis
Eunah Jeong, Wonyong Kim , Seungju Son, Sungyeon Yang , Dasom Gwon, Jihee Hong, Yoonhee Cho, Chang-Young Jang, Martin Steinegger, Young Woon Lim, Kyo Bin Kang
Proceedings of the National Academy of Sciences of the United States of America 120, e2301007120 (2023)Mass spectrometry data on specialized metabolome of medicinal plants used in East Asian traditional medicine
Kyo Bin Kang*, Eunah Jeong, Seungju Son, Eunjin Lee, Seungjin Lee, Seong Yeon Choi, Hyun Woo Kim, Heejung Yang & Sang Hee Shim*
Scientific Data 9, 528 (2022)Cyclohumulanoid sesquiterpenes induced by the noncompetitive coculture of Phellinus orientoasiaticus and Xylodon flaviporus
Huong T. Pham, Thi Phuong Doan, Hyun Woo Kim, Tae Wan Kim, So-Yeon Park, Hangun Kim, Mina Lee, Ki Hyun Kim, Won Keun Oh, Young Woon Lim, Kyo Bin Kang
Journal of Natural Products 85, 511–518 (2022)Tandem mass spectrometry molecular networking as a powerful and efficient tool for drug metabolism studies
Jun Sang Yu, Louis-Félix Nothias, Mingxun Wang, Dong Hyun Kim, Pieter C. Dorrestein, Kyo Bin Kang*, Hye Hyun Yoo*
Analytical Chemistry 94, 1456–1464 (2022)Advances in decomposing complex metabolite mixtures using substructure- and network-based computational metabolomics approaches
Mehdi A. Beniddir#, Kyo Bin Kang#, Grégory Genta-Jouve, Florian Huber, Simon Rogers, Justin J. J. van der Hooft
Natural Product Reports 38, 1967–1993 (2021)Species prioritization based on spectral dissimilarity: A case study of Polyporoid fungal species
Huong T. Pham, Kwang Ho Lee, Eunah Jeong, Sunmin Woo, Jinsuh Yu, Woo-Young Kim, Young Woon Lim, Ki Hyun Kim*, Kyo Bin Kang*
Journal of Natural Products 84, 298–309 (2021)Comprehensive mass spectrometry-guided phenotyping of plant specialized metabolites reveals metabolic diversity in the cosmopolitan plant family Rhamnaceae
Kyo Bin Kang#*, Madeleine Ernst#, Justin J. J. van der Hooft#, Ricardo R. da Silva, Junha Park, Marnix H. Medema, Sang Hyun Sung, Pieter C. Dorrestein*
Plant Journal 98, 1134–1144 (2019)
The full list of papers
2024
Mass spectrometry-based ginsenoside profiling: recent applications, limitations, and perspectives
Hyunwoo Kim, Dae Hyun Kim, Byeol Ryu, You Jin Chung, Kyungha Lee, Young Chang Kim, Jung Woo Lee, Dong Hwi Kim, Woojong Jang, Woohyeon Cho, Hyeonah Shim, Sang Hyun Sung, Tae-Jin Yang, Kyo Bin Kang
Journal of Ginseng Research 48, 149-162MicrobeMASST: A taxonomically-informed mass spectrometry search tool for microbial metabolomics data
Simone Zuffa#, Robin Schmid#, Anelize Bauermeister#, Paulo Wender P. Gomes, Andres M. Caraballo-Rodriguez, Yasin El Abiead, Allegra T. Aron, Emily C. Gentry, Jasmine Zemlin, Michael J. Meehan, Nicole E. Avalon, Robert H. Cichewicz, Ekaterina Buzun, Marvic Carrillo Terrazas, Chia-Yun Hsu, Renee Oles, Adriana Vasquez Ayala, Jiaqi Zhao, Hiutung Chu, Mirte C. M. Kuijpers, Sara L. Jackrel, Fidele Tugizimana, Lerato Pertunia Nephali, Ian A. Dubery, Ntakadzeni Edwin Madala, Eduarda Antunes Moreira, Leticia Veras Costa-Lotufo, Norberto Peporine Lopes, Paula Rezende-Teixeira, Paula C. Jimenez, Bipin Rimal, Andrew D. Patterson, Matthew F. Traxler, Rita de Cassia Pessotti, Daniel Alvarado-Villalobos, Giselle Tamayo-Castillo, Priscila Chaverri, Efrain Escudero-Leyva, Luis-Manuel Quiros-Guerrero, Alexandre Jean Bory, Juliette Joubert, Adriano Rutz, Jean-Luc Wolfender, Pierre-Marie Allard, Andreas Sichert, Sammy Pontrelli, Benjamin S Pullman, Nuno Bandeira, William H. Gerwick, Katia Gindro, Josep Massana-Codina, Berenike C. Wagner, Karl Forchhammer, Daniel Petras, Nicole Aiosa, Neha Garg, Manuel Liebeke, Patric Bourceau, Kyo Bin Kang, Henna Gadhavi, Luiz Pedro Sorio de Carvalho, Mariana Silva dos Santos, Alicia Isabel Perez-Lorente, Carlos Molina-Santiago, Diego Romero, Raimo Franke, Mark Bronstrup, Arturo Vera Ponce de Leon, Phillip Byron Pope, Sabina Leanti La Rosa, Giorgia La Barbera, Henrik M. Roager, Martin Frederik Laursen, Fabian Hammerle, Bianka Siewert, Ursula Peintner, Cuauhtemoc Licona-Cassani, Lorena Rodriguez-Orduna, Evelyn Rampler, Felina Hildebrand, Gunda Koellensperger, Harald Schoeny, Katharina Hohenwallner, Lisa Panzenboeck, Rachel Gregor, Ellis Charles O'Neill, Eve Tallulah Roxborough, Jane Odoi, Nicole J. Bale, Su Ding, Jaap S. Sinninghe Damste, Xueli Li Guan, Jerry J. Cui, Kou-San Ju, Denise Brentan Silva, Fernanda Motta Ribeiro Silva, Gilvan Ferreira da Silva, Hector H. F. Koolen, Carlismari Grundmann, Jason A. Clement, Hosein Mohimani, Kirk Broders, Kerry L. McPhail, Sidnee E. Ober-Singleton, Christopher M. Rath, Daniel McDonald, Rob Knight, Mingxun Wang, Pieter C. Dorrestein
Nature Microbiology 9, 336–343The depside derivative pericodepside inhibits cancer cell metastasis and proliferation by suppressing epithelial−mesenchymal transition
Rui Zhou, Rundong Liu, Kyo Bin Kang, Wonyong Kim, Jae-Seoun Hur, Hangun Kim
ACS Omega 9, 6828–6836Improved biomass and metabolite production in hairy root culture in various genotypes of Panax ginseng through genetic transformation
Van Binh Nguyen, Min Jung Kim, Ngoc Linh Giang Vo, Yun Sun Lee, Murukarthick Jayakodi, Hyun-Seung Park, Padmanaban Mohanan, Kyo Bin Kang, Byeol Ryu, Eun Jin Park, Tae Kyu Park, Tae-Jin Yang
Plant Cell Tissue and Organ Culture 156, 43
2023
Open access repository-scale propagated nearest neighbor suspect spectral library for untargeted metabolomics
Wout Bittremieux*, Nicole E. Avalon, Sydney P. Thomas, Sarvar A. Kakhkhorov, Alexander A. Aksenov, Paulo Wender P. Gomes, Christine M. Aceves, Andrés Mauricio Caraballo-Rodríguez, Julia M. Gauglitz, William H. Gerwick, Tao Huan, Alan K. Jarmusch, Rima F. Kaddurah-Daouk, Kyo Bin Kang, Hyun Woo Kim, Todor Kondić, Helena Mannochio-Russo, Michael J. Meehan, Alexey V. Melnik, Louis-Felix Nothias, Claire O'Donovan, Morgan Panitchpakdi, Daniel Petras, Robin Schmid, Emma L. Schymanski, Justin J. J. van der Hooft, Kelly C. Weldon, Heejung Yang, Shipei Xing, Jasmine Zemlin, Mingxun Wang, Pieter C. Dorrestein*
Nature Communications 14, 8488Discovery of Naphthol tetramers from endolichenic fungus Daldinia childiae 047219 based on MS/MS molecular networking
Jaekyeong Kim, Mei Tong He, Jae-Seoun Hur, Jin Woo Lee, Kyo Bin Kang, Ki Sung Kang, Sang Hee Shim
Journal of Natural Products 86, 2031–2038A fatty acid-rich fraction of an endolichenic fungus Phoma sp. suppresses immune checkpoint markers via AhR/ARNT and ESR1
Mücahit Varlı, Men Thi Ngo, Seong-Min Kim, İsa Taş, Rui Zhou, Chathurika D.B. Gamage, Sultan Pulat, So-Yeon Park, Nüzhet Cenk Sesal, Jae-Seoun Hur, Kyo Bin Kang, Hangun Kim
Heliyon 9, e19185Qualitative metabolomics-based characterization of a phenolic UDP-xylosyltransferase with a broad substrate spectrum from Lentinus brumalis
Eunah Jeong, Wonyong Kim , Seungju Son, Sungyeon Yang , Dasom Gwon, Jihee Hong, Yoonhee Cho, Chang-Young Jang, Martin Steinegger, Young Woon Lim, Kyo Bin Kang
Proceedings of the National Academy of Sciences of the United States of America 120, e2301007120Phthalides isolated from the endolichenic Arthrinium sp. EL000127 exhibits antiangiogenic activity
Chathurika D. B. Gamage#, Kyungha Lee#, So-Yeon Park, Mücahit Varlı, Chang Wook Lee, Seong-Min Kim, Rui Zhou, Sultan Pulat, Yi Yang, İsa Tas,̧ Jae-Seoun Hur, Kyo Bin Kang,* Hangun Kim*
ACS Omega 8, 12548–12557MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters
Barbara R Terlouw#, Kai Blin#, Jorge C Navarro-Muñoz, Nicole E Avalon, Marc G Chevrette, Susan Egbert, Sanghoon Lee, David Meijer, Michael J J Recchia, Zachary L Reitz, Jeffrey A van Santen, Nelly Selem-Mojica, Thomas Tørring, Liana Zaroubi, Mohammad Alanjary, Gajender Aleti, César Aguilar, Suhad A A Al-Salihi, Hannah E Augustijn, J Abraham Avelar-Rivas, Luis A Avitia-Domínguez, Francisco Barona-Gómez, Jordan Bernaldo-Agüero, Vincent A Bielinski, Friederike Biermann, Thomas J Booth, Victor J Carrion Bravo, Raquel Castelo-Branco, Fernanda O Chagas, Pablo Cruz-Morales, Chao Du, Katherine R Duncan, Athina Gavriilidou, Damien Gayrard, Karina Gutiérrez-García, Kristina Haslinger, Eric J N Helfrich, Justin J J van der Hooft, Afif P Jati, Edward Kalkreuter, Nikolaos Kalyvas, Kyo Bin Kang, Satria Kautsar, Wonyong Kim, Aditya M Kunjapur, Yong-Xin Li, Geng-Min Lin, Catarina Loureiro, Joris J R Louwen, Nico L L Louwen, George Lund, Jonathan Parra, Benjamin Philmus, Bita Pourmohsenin, Lotte J U Pronk, Adriana Rego, Devasahayam Arokia Balaya Rex, Serina Robinson, L Rodrigo Rosas-Becerra, Eve T Roxborough, Michelle A Schorn, Darren J Scobie, Kumar Saurabh Singh, Nika Sokolova, Xiaoyu Tang, Daniel Udwary, Aruna Vigneshwari, Kristiina Vind, Sophie P J M Vromans, Valentin Waschulin, Sam E Williams, Jaclyn M Winter, Thomas E Witte, Huali Xie, Dong Yang, Jingwei Yu, Mitja Zdouc, Zheng Zhong, Jérôme Collemare, Roger G Linington, Tilmann Weber*, Marnix H Medema*
Nucleic Acids Research 51, D603–D610Comparative transcriptome and metabolome analyses of four Panax species explore the dynamics of metabolite biosynthesis
Hyunjin Koo#, Yun Sun Lee#, Van Binh Nguyen, Vo Ngoc Linh Giang, Hyun Jo Koo, Hyun-Seung Park, Padmanaban Mohanan, Young Hun Song, Byeol Ryu, Kyo Bin Kang, Sang Hyun Sung, Tae-Jin Yang
Journal of Ginseng Research 47, 44–53
2022
A universal language for finding mass spectrometry data patterns
Alan K. Jarmusch#, Allegra T. Aron#, Daniel Petras, Vanessa V. Phelan, Wout Bittremieux, Deepa D. Acharya, Mohammed M. A. Ahmed, Anelize Bauermeister, Matthew J. Bertin, Paul D. Boudreau, Ricardo M. Borges, Benjamin P. Bowen, Christopher J. Brown, Fernanda O. Chagas, Kenneth D. Clevenger, Mario S. P. Correia, William J. Crandall, Max Crüsemann, Tito Damiani, Oliver Fiehn, Neha Garg, William H. Gerwick, Jeffrey R. Gilbert, Daniel Globisch, Paulo Wender P. Gomes, Steffen Heuckeroth, C. Andrew James, Scott A. Jarmusch, Sarvar A. Kakhkhorov, Kyo Bin Kang, Roland D Kersten, Hyunwoo Kim, Riley D. Kirk, Oliver Kohlbacher, Eftychia E. Kontou, Ken Liu, Itzel Lizama-Chamu, Gordon T. Luu, Tal Luzzatto Knaan, Michael T. Marty, Andrew C. McAvoy, Laura-Isobel McCall, Osama G. Mohamed, Omri Nahor, Timo H. J. Niedermeyer, Trent R. Northen, Kirsten E. Overdahl, Tomáš Pluskal, Johannes Rainer, Raphael Reher, Elys Rodriguez, Timo T. Sachsenberg, Laura M. Sanchez, Robin Schmid, Cole Stevens, Zhenyu Tian, Ashootosh Tripathi, Hiroshi Tsugawa, Kozo Nishida, Yuki Matsuzawa, Justin J.J. van der Hooft, Andrea Vicini, Axel Walter, Tilmann Weber, Quanbo Xiong, Tao Xu, Haoqi Nina Zhao, Pieter C. Dorrestein, Mingxun Wang
BioRxiv (preprint) 2022.08.06.503000An acetonic extract and secondary metabolites from the endolichenic fungus Nemania sp. EL006872 exhibit immune checkpoint inhibitory activity in lung cancer cell
Mücahit Varli, Huong T. Pham, Seong-Min Kim, İsa Taş, Chathurika D. Gamage, Rui Zhou, Sultan Pulat, So-Yeon Park, Nüzhet C. Sesal, Jae-Seoun Hur, Kyo Bin Kang, Hangun Kim
Frontiers in Pharmacology 13, 986946Mass spectrometry data on specialized metabolome of medicinal plants used in East Asian traditional medicine
Kyo Bin Kang*, Eunah Jeong, Seungju Son, Eunjin Lee, Seungjin Lee, Seong Yeon Choi, Hyun Woo Kim, Heejung Yang & Sang Hee Shim*
Scientific Data 9, 528Cyclohumulanoid sesquiterpenes induced by the noncompetitive coculture of Phellinus orientoasiaticus and Xylodon flaviporus
Huong T. Pham, Thi Phuong Doan, Hyun Woo Kim, Tae Wan Kim, So-Yeon Park, Hangun Kim, Mina Lee, Ki Hyun Kim, Won Keun Oh, Young Woon Lim, Kyo Bin Kang
Journal of Natural Products 85, 511–518Identification of antibacterial sterols from Korean wild mushroom Daedaleopsis confragosa via bioactivity- and LC-MS/MS profile-guided fractionation
Myung Woo Na, Eunjin Lee, Dong-Min Kang, Se Yun Jeong , Rhim Ryoo, Chul-Young Kim, Mi-Jeong Ahn, Kyo Bin Kang* , Ki Hyun Kim*
Molecules 37, 1865Genetic and chemical markers for authentication of three Artemisia species: A. capillaris, A. gmelinii, and A. fukudo
Yun Sun Lee#, Sunmin Woo#, Jin-Kyung Kim, Jee Young Park, Nur Kholilatul Izzah, Hyun-Seung Park, Jung Hwa Kang, Taek Joo Lee, Sang Hyun Sung, Kyo Bin Kang*, Tae-Jin Yang*
PLoS One 17, e0264576Tandem mass spectrometry molecular networking as a powerful and efficient tool for drug metabolism studies
Jun Sang Yu, Louis-Félix Nothias, Mingxun Wang, Dong Hyun Kim, Pieter C. Dorrestein, Kyo Bin Kang*, Hye Hyun Yoo*
Analytical Chemistry 94, 1456–1464
2019 – 2021
2021
LC–MS/MS-based comparative investigation on chemical constituents of six Aster species occurring in Korea
Kyo Bin Kang*, Dong Young Lee, Sang Hyun Sung
Natural Product Sciences 27, 257–263NPClassifier: A deep neural network-based structural classification tool for natural products
Hyunwoo Kim, Mingxun Wang, Christopher Leber, Louis-Félix Nothias, Raphael Reher, Kyo Bin Kang, Justin J. J. van der Hooft, Pieter C. Dorrestein, William H. Gerwick*, Garrison W. Cottrell*
Journal of Natural Products 84, 2795–2807Advances in decomposing complex metabolite mixtures using substructure- and network-based computational metabolomics approaches
Mehdi A. Beniddir#, Kyo Bin Kang#, Grégory Genta-Jouve, Florian Huber, Simon Rogers, Justin J. J. van der Hooft
Natural Product Reports 38, 1967–1993Antioxidant and anti-inflammatory effects of 3-dehydroxyceanothic acid 2-methyl ester isolated from Ziziphus jujuba Mill. against cisplatin-induced kidney epithelial cell death
Dahae Lee#, Kyo Bin Kang#, Gwi Seo Hwang, You-Kyoung Choi, Tae Kon Kim*, Ki Sung Kang*
Biomolecules 11, 1614Linking a gene cluster to atanorin, a major cortical substance of lichens, through genetic dereplication and heterologous expression
Wonyong Kim*, Rundong Liu, Sunmin Woo, Kyo Bin Kang, Hyun Park, Young Hyun Yu, Hyung-Ho Ha, Seung-Yoon Oh, Ji Ho Yang, Hangun Kim, Sung-Hwan Yun, Jae-Seoun Hur*
mBio 12, e01111-21Chemical and biological profiles of Dendrobium in two different species, their hybrid, and gamma-irradiated mutant lines of the hybrid based on LC-QToF MS and cytotoxicity analysis
Bomi Nam#, Hyun-Jae Jang#, Ah-Reum Han#, Ye-Ram Kim, Chang-Hyun Jin, Chan-Hun Jung, Kyo-Bin Kang, Sang-Hoon Kim, Min-Jeong Hong, Jin-Baek Kim, Hyung-Won Ryu
Plants 10, 1376A metabolic choreography of maize plants treated with a humic substance-based biostimulant under normal and starved conditions
Kgalaletso Othibeng, Lerato Nephali, Anza-Tshilidzi Ramabulana, Paul Steenkamp, Daniel Petras, Kyo Bin Kang, Hugo Opperman, Johan Huyser, Fidele Tugizimana
Metabolites 11, 403FgPKS7 is an essential player in mating-type-mediated regulatory pathway required for completing sexual cycle in Fusarium graminearum
Da-Woon Kim, Yoo-Kyoung Shin, Sang-Won Lee, Kanphassorn Wimonmuang, Kyo Bin Kang, Young-Sang Lee, Sung-Hwan Yun
Environmental Microbiology 23, 1972–1990A community resource for paired genomic and metabolomic data mining
Michelle A. Schorn#, Stefan Verhoeven#, Lars Ridder, Florian Huber, ... , Kyo Bin Kang, ... , Katherine R. Duncan, Max Crüsemann, Simon Rogers, Pieter C. Dorrestein*, Marnix H. Medema*, Justin J. J. van der Hooft*
Nature Chemical Biology 17, 363–368Species prioritization based on spectral dissimilarity: A case study of Polyporoid fungal species
Huong T. Pham, Kwang Ho Lee, Eunah Jeong, Sunmin Woo, Jinsuh Yu, Woo-Young Kim, Young Woon Lim, Ki Hyun Kim*, Kyo Bin Kang*
Journal of Natural Products 84, 298–309Assessing the genetic and chemical diversity of Taraxacum species in the Korean Peninsula
Yun Sun Lee#, Jinkyung Kim#, Sunmin Woo#, Jee Young Park, Hyun-Seung Park, Hyeonah Shim, Hong-Il Choi, Jung Hwa Kang, Taek Joo Lee, Sang Hyun Sung, Tae-Jin Yang*, Kyo Bin Kang*
Phytochemistry 181, 112576
2020
Simultaneous determination of two diterpenoids, continentalic acid and kaurenoic acid, in the water extract of Aralia continentalis and their wound-healing activity
Guijae Yoo, Taek Hwan Lee, Jae Hyuk Lee, Kyo Bin Kang, Heejung Yang, Yong Kon Park, Sun Yeou Kim, Seung Hyun Kim
Pharmacognosy Magazine 16, 745–749Feature-based molecular networking in the GNPS analysis environment
Louis-Félix Nothias#, Daniel Petras#, Robin Schmid#, ... , Kyo Bin Kang, ... , Mingxun Wang*, Pieter C. Dorrestein*
Nature Methods 17, 905–908Combined MS/MS-NMR annotation guided discovery of Iris lactea var. chinensis seed as a source of viral neuraminidase inhibitory polyphenols
Hyun Woo Kim, Soo Sung Kim, Kyo Bin Kang, Byeol Ryu, Eunjin Park, Jungmoo Huh, Won Kyung Jeon, Hee-Sung Chae, Won Keun Oh, Jinwoong Kim, Sang Hyun Sung, Young-Won Chin
Molecules 25, 3383Reproducible molecular networking of untargeted mass spectrometry data using GNPS
Allegra T. Aron#, Emily C. Gentry#, Kerry L. McPhail#, ... , Kyo Bin Kang, ... , Nuno Bandeira*, Mingxun Wang*, Pieter C. Dorrestein*
Nature Protocols 15, 1954–1991Unique triterpenoid of jujube root protects cisplatin-induced damage in kidney epithelial LLC-PK1 cells via autophagy regulation
Dahae Lee#, Kyo Bin Kang#, Hyun Woo Kim, Jung Sik Park, Gwi Seo Hwang, Ki Sung Kang, Sungyoul Choi, Noriko Yamabe*, Ki Hyun Kim*
Nutrients 12, 677Assessing specialized metabolite diversity of Alnus species by a digitized LC–MS/MS data analysis workflow
Kyo Bin Kang*, Sunmin Woo, Madeleine Ernst, Justin J. J. van der Hooft, Louis-Félix Nothias, Ricardo R. da Silva, Pieter C. Dorrestein, Sang Hyun Sung, Mina Lee*
Phytochemistry 173, 112292Untargeted mass spectrometry-based metabolomics approach unveils molecular changes in raw and processed foods and beverages
Julia M. Gauglitz, Christine M. Aceves, Alexander A. Aksenov, Gajender Aleti, Jehad Almaliti, Amina Bouslimani, ... , Kyo Bin Kang, ... , Pieter C. Dorrestein
Food Chemistry 302, 125290
2019
Identification and semi-synthesis of 3-O-protocatechuoylceanothic acid, a novel and natural GPR120 agonist
Changjin Lim, Jung Gyu Park, Kyo Bin Kang, Young-Ger Suh
Molecules 24, 3487Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
Evan Bolyen#, Jai Ram Rideout#, Matthew R. Dillon#, Nicholas A. Bokulich#, ... , Kyo Bin Kang, ... , Rob Knight, J. Gregory Caporaso
Nature Biotechnology 37, 852–857MolNetEnhancer: enhanced molecular networks by integrating metabolome mining and annotation tools
Madeleine Ernst*, Kyo Bin Kang, Andrés Mauricio Caraballo-Rodríguez, Louis-Felix Nothias, Joe Wandy, Christopher Chen, Mingxun Wang, Simon Rogers, Marnix H. Medema, Pieter C. Dorrestein, Justin J.J. van der Hooft*
Metabolites 9, 144Molecular networking reveals the chemical diversity of selaginellin derivatives, natural phosphodiesterase-4 inhibitors from Selaginella tamariscina
Sunmin Woo, Kyo Bin Kang*, Jinwoong Kim*, Sang Hyun Sung
Journal of Natural Products 82, 1820–1830Comprehensive mass spectrometry-guided phenotyping of plant specialized metabolites reveals metabolic diversity in the cosmopolitan plant family Rhamnaceae
Kyo Bin Kang#*, Madeleine Ernst#, Justin J. J. van der Hooft#, Ricardo R. da Silva, Junha Park, Marnix H. Medema, Sang Hyun Sung, Pieter C. Dorrestein*
Plant Journal 98, 1134–1144Multiple targets of 3-dehydroxyceanothetric acid 2-methyl ester to protect cisplatin-induced cytotoxicity in kidney epithelial LLC-PK1 cells
Dahae Lee#, Ki Hyun Kim#, Won Yung Lee, Chang-Eop Kim, Sang Hyun Sung, Kyo Bin Kang*, Ki Sung Kang*
Molecules 24, 878
2011 – 2018 (before SMWU)
Classification of Bupleuri Radix according to geographical origins using near infrared spectroscopy (NIRS) combined with supervised pattern recognition
Dong Young Lee, Kyo Bin Kang, Jina Kim, Hyo Jin Kim, Sang Hyun Sung
Natural Product Sciences 24, 164–170 (2018)Genome and evolution of the shade-requiring medicinal herb Panax ginseng
Nam-Hoon Kim, Murukarthick Jayakodi, Sang-Choon Lee, Beom-Soon Choi, Woojong Jang, Junki Lee, Hyun Hee Kim, Nomar E. Waminal, Meiyappan Lakshmanan, Binh van Nguyen, Yun Sun Lee, Hyun-Seung Park, Hyun Jo Koo, Jee Young Park, Sampath Perumal, Ho Jun Joh, Hana Lee, Jinkyung Kim, In Seo Kim, Kyunghee Kim, Lokanand Koduru, Kyo Bin Kang, Sang Hyun Sung, Yeisoo Yu, Daniel S. Park, Doil Choi, Eunyoung Seo, Seungil Kim, Young-Chang Kim, Dong Yun Hyun, Youn-Il Park, Changsoo Kim, Tae-Ho Lee, Hyun Uk Kim, Moon Soo Soh, Yi Lee, Jun Gyo In, Heui-Soo Kim, Young-Min Kim, Deok-Chun Yang, Rod A. Wing, Dong-Yup Lee, Andrew H. Paterson, Tae-Jin Yang
Plant Biotechnology Journal 16, 1904–1917 (2018)Targeted isolation of neuroprotective dicoumaroyl neolignans and lignans from Sageretia theezans using in silico molecular network annotation propagation-based dereplication
Kyo Bin Kang#*, Eun Jin Park#, Ricardo R. da Silva, Hyun Woo Kim, Pieter C. Dorrestein*, Sang Hyun Sung
Journal of Natural Products 81, 1819–1828 (2018)The complete chloroplast genome sequence of Korean Lonicera japonica and intra-species diversity
Shin-Jae Kang, Hyun-Seung Park, Hyun Jo Koo, Jee Young Park, Dong Young Lee, Kyo Bin Kang, Sang Il Han, Sang Hyun Sung, Tae-Jin Yang
Mitochondrial DNA Part B 3, 943–944 (2018)Chemical and genomic diversity of six Lonicera species occurring in Korea
Kyo Bin Kang*, Shin-Jae Kang, Mi Song Kim, Dong Young Lee, Sang Il Han, Tae Bum Kim, Jee Young Park, Jinwoong Kim, Tae-Jin Yang*, Sang Hyun Sung
Phytochemistry 155, 126–135 (2018)Identification of candidate UDP-glycosyltransferases involved in protopanaxadiol-type ginsenoside biosynthesis in Panax ginseng
Kyo Bin Kang#*, Murukarthick Jayakodi#, Yun Sun Lee#, Van Binh Nguyen, Hyun-Seung Park, Hyun Jo Koo, Ik Young Choi, Dae Hyun Kim, You Jin Chung, Byeol Ryu, Dong Young Lee, Sang Hyun Sung, Tae-Jin Yang*
Scientific Reports 8, 11744 (2018)Simultaneous determination and stability test of two phthalic anhydride derivatives, senkyunolide A and Z-ligustilide, in the water extract of Cnidium Rhizome from different geographical regions and species using HPLC–UVD analysis
Hyeon Seok Jang, Kyo Bin Kang, Guijae Yoo, Euna Kwon, Jun-Won Yun, Byeong-Cheol Kang, In Kee Hong, Seung Hyun Kim, Sang Hyun Sung, Hyun-Jong Cho, Young Pyo Jang, Heejung Yang
Bulletin of the Korean Chemical Society 39, 784–788 (2018)Rhamnellosides A and B, ω-phenylpentaene fatty acid amide diglycosides from the fruits of Rhamnella franguloides
Kyo Bin Kang#, Ming Gao#, Geum Jin kim, Hyukjae Choi*, Sang Hyun Sung*
Molecules 23, 752 (2018)Argininosecologanin, a secoiridoid-derived guanidine alkaloid from the roots of Lonicera insularis
Kyo Bin Kang#, Dong Young Lee#, Mi Song Kim, Tae Bum Kim, Tae-Jin Yang, Sang Hyun Sung
Natural Product Research 32, 788–794 (2018)
C-methylated flavonoid glycosides from Pentarhizidium orientale rhizome and their inhibitory effects on the H1N1 influenza virus
Jungmoo Huh, Thi Kim Quy Ha, Kyo Bin Kang, Ki Hyun Kim, Won Keun Oh, Jinwoong Kim, Sang Hyun Sung
Journal of Natural Products 80, 2818–2824 (2017)Berchemiosides A–C, 2-acetoxy-ω-phenylpentaene fatty acid triglycosides from the unripe fruits of Berchemia berchemiifolia
Kyo Bin Kang, Eun Jin Park, Jinwoong Kim, Sang Hyun Sung
Journal of Natural Products 80, 2778–2786 (2017)Simultaneous determination of gastrodin and gastrodigenin in Gastrodia elata by HPLC–UV
Kyo Bin Kang, Jin Bum Jun, Guijae Yoo, Euna Kwon, Jun-Won Yun, Byeong-Cheol Kang, Seung Hyun Kim, Sang Hyun Sung , Young Pyo Jang, Heejung Yang
Korean Journal of Pharmacognosy 48, 232–236 (2017)Ceanothane- and lupane-type triterpene esters from the roots of Hovenia dulcis and their antiproliferative activity on HSC-T6 cells
Kyo Bin Kang, Jin Bum Jun, Jung Wha Kim, Hyun Woo Kim, Sang Hyun Sung
Phytochemistry 142, 60–67 (2017)Catechin-bound ceanothane-type triterpenoid derivatives from the roots of Zizyphus jujuba
Kyo Bin Kang, Hyun Woo Kim, Jung Wha Kim, Won Keun Oh, Jinwoong Kim, Sang Hyun Sung
Journal of Natural Products 80, 1048–1054 (2017)Combined application of UHPLC–QTOF/MS, HPLC–ELSD and 1H NMR spectroscopy for quality assessment of DA-9801, a standardised Dioscorea extract
Kyo Bin Kang, Jayoung Ryu, Youngwoong Cho, Sang-Zin Choi, Miwon Son, Sang Hyun Sung
Phytochemical Analysis 28, 185–194 (2017)Antiplasmodial activity, cytotoxicity and structure-activity relationship study of cyclopeptide alkaloids
Emmy Tuenter, Karen Segers, Kyo Bin Kang, Johan Viaene, Sang Hyun Sung, Paul Cos, Louis Maes, Yvan Vander Heyden, Luc Pieters
Molecules 22, 224 (2017)
Acylphloroglucinolated catechin and phenylethyl isocoumarin derivatives from Agrimonia pilosa
Hyun Woo Kim, Junha Park, Kyo Bin Kang, Tae Bum Kim, Won Keun Oh, Jinwoong Kim, Sang Hyun Sung
Journal of Natural Products 79, 2376–2383 (2016)Cytotoxic ceanothane- and lupane-type triterpenoids from the roots of Ziziphus jujuba
Kyo Bin Kang, Jung Wha Kim, Won Keun Oh, Jinwoong Kim, Sang Hyun Sung
Journal of Natural Products 79, 2364–2375 (2016)UHPLC–ESI-qTOF-MS analysis of cyclopeptide alkaloids in the seeds of Ziziphus jujuba var. spinosa
Kyo Bin Kang, Dae Sik Jang, Jinwoong Kim, Sang Hyun Sung
Mass Spectrometry Letters 7, 45–49 (2016)Ginsenoside 20(S)-Rh2 exerts anti-cancer activity through targeting IL-6-induced JAK2/STAT3 pathways in human colorectal cancer cells
Songhee Han, Ae Jin Jeong, Heejung Yang, Kyo Bin Kang, Haeri Lee, Eun Hee Yi, Byung-Hak Kim, Chung-Hyun Cho, Jin Woong Chung, Sang Hyun Sung, Sang-Kyu Ye
Journal of Ethnopharmacology 194, 83–90 (2016)
Jubanines F-J, cyclopeptide alkaloids from the roots of Ziziphus jujuba
Kyo Bin Kang, Gao Ming, Geun Jin Kim, Thi-Kim-Quy Ha, Hyukjae Choi, Won Keun Oh, Sang Hyun Sung
Phytochemistry 119, 90–95 (2015)Anti-influenza activity of betulinic acid from Zizyphus jujuba on influenza A/PR/8 virus
Eun-Hye Hong, Jae Hyoung Song, Kyo Bin Kang, Sang Hyun Sung, Hyun-Jeong Ko, Heejung Yang
Biomolecules & Therapeutics 23, 345–349 (2015)Identification of ginsenoside markers from dry purified extract of Panax ginseng by a dereplication approach and UPLC–QTOF/MS analysis
Heejung Yang, Dong Young Lee, Kyo Bin Kang, Jeom Yong Kim, Sun Ok Kim, Young Hyo Yoo, Sang Hyun Sung.
Journal of Pharmaceutical and Biomedical Analysis 109, 91–104 (2015)
Prediction of tyrosinase inhibitory activities of Morus alba root bark extracts from HPLC fingerprints
Kyo Bin Kang, Dong Young Lee, Tae Bum Kim, Seung Hyun Kim, Hyo Jin Kim, Jinwoong Kim, Sang Hyun Sung
Microchemical Journal 110, 731–738 (2013)
Tyrosinase inhibitory constituents of Morus bombycis cortex
Kyo Bin Kang, Sang Du Kim, Tae Bum Kim, Eun Ju Jeong, Young Choong Kim, Jong Hyuk Sung, Sang Hyun Sung.
Natural Product Sciences 17, 198–201 (2011)