Natural Product Chemistry Lab @ Sookmyung Women's University

Multiomics-based Fungal Natural Product Discovery

Natural products are the one of major sources of chemical diversity for drug discovery. In history of evolution, chemical diversity of natural products has been accumulated as results of various species' adaptation to environment. Thus, tracking the evolutionary history of chemical diversity in systemic view provides us many insights and possibilities on new chemical entity discovery. Recent advances in mass spectrometry (MS) allows us to acquire enormous data about chemical diversity of natural products, and advances in MS-related bioinformatics tools convert the data into information. In our lab, we study on chemical diversity of natural products made by plants and fungi systemically using MS and bioinformatics to get insights on chemoevolution of plants, then apply them to natural product-based drug discovery.

Research Fundings on this theme:

June 2022 - Feb 2029 근육피지옴연구센터 (Muscle Physiome Research Center)
National Research Foundation of Korea, MRC (연구재단 선도연구센터) #2022R1A5A2021216
Mar 2020 - Feb 2025 대사유전체학 기반의 국내 자생 진균 유래 천연물 발굴 (Metabologenomics-based natural product discovery from Korean fungi)
National Research Foundation of Korea, Young Scientist Grants Outstanding Track (연구재단 신진연구) #2020R1C1C1004046
Jun 2019 - May 2020 Bioactive natural product discovery from Polyporaceae mushrooms based on metabolites profiling
National Research Foundation of Korea, General Grants (연구재단 기본연구) #2019R1F1A1058068

Systemic Analysis on Symbiotic Lichen Chemistry

Lichen is a symbiotic system consisting of multiple fungi species living with algae or cyanobacteria in a mutualistic relationship. Because of its complex symbiosis, it has drawn many scientist's interest but the difficulty in analyzing the complex chemistry and biology. However, recent advances in genomics and analytical chemistry allow us to look into these fascinating organisms. In our lab, we use mass spectrometry-based metabolomics techniques to discover molecules involved in chemical interaction within the lichen. This will not only give us scientific insights on the symbiotic system, but also provide us the possibility of using lichen chemicals to enhance our health, especially as new drug discovery leads.

Quality Evaluation of Botanical Drugs

Development of suitable quality control methods has been considered as a crucial issue for standardization and modernization of herbal drug products. Complicated compositions of herbal drugs have made it difficult to identify their components both qualitatively and quantitatively. However, recent technical advances are improving accuracy and resolution of chemical analysis of herbal medicines, so holistic approach-based analytical methods have been proposed as alternative methods for quality assessment of herbal medicines. In our lab, we are trying to develop proper quality evaluation methods for botanical products (drugs, foods, cosmetics et al.) by applying modern analytic platforms, such as LC-MS/MS, NMR, FT-NIR.

Research Fundings on this theme:

Feb 2021 - Dec 2023 "한약(생약)제제 품질평가 기술개발 연구 (Development of techniques for herbal medicine product quality evaluation)
Ministry of Food and Drug Safety (식약처 출연연구) #21173MFDS561